Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3
نویسندگان
چکیده
منابع مشابه
Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines
PURPOSE To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs (IVDs). Responsiveness to these cytokines according to the degree of disc degeneration was also evaluated. MATERIALS AND METHODS The disc specimens were classified into two...
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Degenerative disc disease (DDD) is a common degenerative condition initiated mainly within the nucleus pulposus (NP). To date, the etiopathogenesis of DDD remains unclear, and because no effective therapeutic strategies are available to target its pathological processes, DDD is still treated with symptomatic interventions that are far from adequate. Collagen type II is one of the major matrix c...
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PURPOSE This study investigated the expression and function of the microRNA-494 in intervertebral disc degeneration (IDD). RESULTS MicroRNA-494 expression was upregulated during IDD progression; its overexpression increased the expression of ECM catabolic factors such as matrix metalloproteinase and A disintegrin and metalloproteinase with thrombospondin motif in NP cells while decreasing tha...
متن کاملIL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells
IL-1β has been reported highly expressed in degenerative intervertebral disc, and our previous study indicated IL-1β facilitates apoptosis of human degenerative nucleus pulposus (NP) cell. However, the underlying molecular mechanism remains unclear. We here demonstrate that IL-1β played a significantly pro-apoptotic effect under serum deprivation. IL-1β decreased Bcl-2/Bax ratio and enhanced cy...
متن کاملSIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
SIRT1 could protect degenerative human NP cells against apoptosis, and there were extensive and intimate connection between apoptosis and autophagy. Up to now, the role of autophagy in the process of human IVD degeneration is unclear. We sought to explore the relationship between autophagy and human IVD degeneration and to understand whether autophagy is involved in the protective effect of SIR...
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ژورنال
عنوان ژورنال: Journal of Spinal Disorders & Techniques
سال: 2013
ISSN: 1536-0652
DOI: 10.1097/bsd.0b013e31826e0ca4